Comprehensive Genetic Interaction Map Created for Tuberculosis Bacteria

• Rockefeller scientists created a comprehensive map of essential gene interactions in Mycobacterium tuberculosis.
• The map reveals thousands of previously unknown genetic relationships in the bacterium responsible for tuberculosis.
• The high-throughput CRISPR-interference platform was used to map interactions between essential genes in Mycobacterium tuberculosis.
• The findings provide insight into gene function and drug–target relationships, potentially enabling the development of new therapies.
• The research was published in Nature on November 4, 2026.